Tuberous Sclerosis, the rare genetic condition also known as Tuberous Sclerosis complex (TSC), is the cause of tumors found throughout the body. These enlargements are not harmful but Tuberous Sclerosis treatment cost in India may be high. However, benign tumors are abnormal growths of tissue and cells which are also known as non-cancerous tumors.

Early childhood or infancy is when most cases of Tuberous Sclerosis start. Sometimes the disease is misdiagnosed or not identified until adulthood because the signs and symptoms of Tuberous Sclerosis are so mild. Significant impairment can occasionally result from Tuberous Sclerosis.

It is impossible to monitor the progression of Tuberous Sclerosis over time, and there is no known treatment for the condition. There are techniques, nevertheless, to lessen symptoms.

One possible cause of Tuberous Sclerosis is a mutation in the TSC1 or TSC2 genes, which regulate tuberin and hamartin, respectively. Together, these genes control how cells divide, develop, and enlarge.

Symptoms of Tuberous Sclerosis

Every instance of Tuberous Sclerosis presents with a unique set of symptoms which are as follows:

• Anger, hyperactivity, self-harm, and difficulties adjusting emotionally or socially are a few instances of behavioral disorders.

• The emergence of pale spots on the skin, tiny, harmless skin thickenings, or reddish lumps under or surrounding the nails. Early in infancy, facial growths that resemble pimples are common.

• Cardiac issues, such as hypertrophy, may indicate the presence of Tuberous Sclerosis. In this case, cardiac growths peak at birth and thereafter start to diminish.

• Seizures in children may be the initial indication of a brain tumor that is growing.

• Non-cancerous kidney growth could potentially be a sign of this illness.

• Coughing or dyspnea during exercise or physical activity may be caused by lung growth.

• Ocular growth may be indicated by retinal white patches.

• Two further possible effects of Tuberous Sclerosis are developmental delays and cognitive deficits. ADHD and autism spectrum disorder are two mental health conditions that may be connected to this issue.

Risk of Tuberous Sclerosis

Tuberous Sclerosis treatment cost in India varies person to person according to their health condition. One’s risk of acquiring Tuberous Sclerosis may be increased by the following factors:

1. Genetic inheritance: Due to autosomal dominance in either the mother or the father, a gene copy has a 50% chance of being passed on during pregnancy.
2. Errors made unintentionally during cell division: mutations in the genes that hinder tumor growth and new diseases have the potential to arise as a result of TSC1 and TSC2.

Possible Complications

• Lesions may result in bleeding, hematuria, unpleasant abdominal lumps, and flank pain.

• If the illness affects many organs, the problems from the condition may worsen.

• Infants with cardiac rhabdomyoma, a type of heart tumor, may die. One of the outcomes could be the impact on the kidneys. Patients may develop renal cell carcinomas cysts, and polycystic kidney disease, renal lesions as a result of these disorders. Furthermore, asymptomatic renal angiomyolipomas are prevalent.

• Lung cyst anomalies can develop as a result of a disorder called lymphangiomyomatosis. Cortical or subcortical tubers, Subependymal nodules, and symptomatic subependymal giant cell astrocytomas are examples of symptoms associated with the central nervous system that could cause complications. The tubers could harm the patient’s cognitive function or produce seizures.

Monitoring the condition of Tuberous Sclerosis

Testing should be done frequently for those with Tuberous Sclerosis. This allows for routine monitoring and assessment of the functioning of the kidneys, lungs, and brain—the organs most frequently affected by the illness. Condition may impact the Tuberous Sclerosis treatment cost in India differently.

It could be wise to do the assessments and trials listed below:

• Blood tests: to evaluate levels of vitamin D, renal function, and other components.

• Ultrasound scans: for the detection of cardiac and renal malignancies.

• MRI scans: to check for changes in cancers of the brain or kidney.

• Measurements of blood pressure.

• Abnormal electrical activity in the heart is identified by electrocardiograms or ECGs.

• Concerns about your child’s development and conduct.

• Pay attention to any changes that occur to the skin or eyes.

• Examining a person’s expiratory gas exchange capacity and lung function should be done via CT scans.

Epilepsy in Tuberous Sclerosis treatment cost in India

The neurological condition known as epilepsy, which can significantly lower a person’s quality of life, is characterized by recurrent seizures. Medication and other conventional therapies might not work effectively for some people. Epilepsy surgery becomes a feasible option under certain conditions, offering hope for a life free of seizures. To clarify the nuances of epilepsy surgery in India, you shorld aware of the procedure, success rates, and related expenses.

Epilepsy surgery 

The nature of the epilepsy, the location of the seizure, and the overall health of the patient all affect how well epilepsy surgery proceeds. In addition, it will help you identify the actual Tuberous Sclerosis treatment cost in India easily. Studies show that a considerable percentage of individuals have either a large decrease in the frequency of seizures or complete seizure independence following surgery. 

One of the main concerns for many people with epilepsy is Tuberous Sclerosis treatment cost in India without additional charges. India’s excellent healthcare system and reasonably priced medical services are drawing more and more visitors looking for medical attention to the country. As success rates can vary, patients should carefully examine whether or not they are a good candidate for the operation.

The epilepsy surgery cost varies in India based on the procedure, facilities provided by the hospital, and experience of the surgical team. For foreign patients seeking excellent care at a reasonable cost, India is the greatest choice because its expenses are typically lower than those of many Western nations.

Every operation for epilepsy requires careful assessment and coordination between patients, families, and medical staff. Contacting skilled neurosurgeons and epileptologists is essential, as they may offer personalized advice based on each patient’s particular medical background and diagnostic results. Furthermore, by being aware of the expenses and success rates related to epilepsy surgery in India, anyone can make an informed therapeutic decision.

For those looking for a practical way to control their seizures, epilepsy surgery is an option in India. Serving as a thorough guide, this blog provides essential information to help individuals cope with the consequences of epilepsy surgery and eventually enhance their quality of life.

Epilepsy Surgery Cost In India

An epilepsy treatment cost in India could be between Rs. 1.5 lakh to Rs. 15 lakh, or $1,198 and $18,000 in US dollars. This includes the expense of assessment in addition to operating. The cost of epilepsy surgery is comparatively affordable in India as compared to other developed countries such as the US and the UK. In contrast, the US may charge anywhere from $15,000 to $25,000 for the same therapy.

The epilepsy surgery cost varies in India based on several factors, including:

• The hospital and the Department of Admissions

• The cost of any issues or follow-up treatment.

• Health care and other personnel costs.

• The kind of surgery used to treat epilepsy.

• Length of hospitalization.

• The cost of pre-and post-operative tests as well as recommended drugs.

The following are the most common kinds of epilepsy surgery carried out in India:

Neuromodulation surgery: this involves implanting a device, such as a vagus nerve stimulator (VNS), responsive neurostimulator (RNS), or deep brain stimulator (DBS), that can stimulate or inhibit certain brain regions or nerves linked to the development of seizures. Patients who are not responsive to disconnection or reconstructive surgery and have drug-resistant epilepsy are often suggested for this operation. The average cost of neuromodulation surgery in India is approximately Rs. 6,00,000. The most that can be paid in India for neuromodulation surgery is Rs. 10,000,000.

Disconnection surgery: In this procedure, pieces of the nerve fibers that link to different parts of the brain, including the corpus callosum and several subpial transections, are severed or disconnected. Patients with seizures that affect both sides of the brain, or those with generalized epilepsy, are usually the ones who undergo this procedure. In India, a disconnection procedure usually cost approximately Rs. 3,00,000. In India, there is a maximum payment of Rs. 5,00,000 for a disconnection procedure.

Resective surgery: In this treatment, a small area of the brain that is responsible for the seizures is removed, such as the frontal, temporal, or parietal lobes. Patients who have focal epilepsy, a disorder where seizures seem to come from a particular area of the brain, typically go through this process. In India, the average cost of resective surgery is about Rs. 250,000. Currently, the highest sum that can be allocated for resective surgery in India is Rs. 427900.

Depending on the intricacy and duration of the required testing, surgical assessments for epilepsy might be expensive in India. 

A procedure could consist of:

1. An MRI to see how the brain functions and is composed.
2. Extensive physical examination and medical history.
3. A detailed map of the brain’s electrical activity using magnetoencephalography (MEG) or electrocorticography (ECoG).
4. A device used to record brain waves and seizures is called a video-electroencephalogram (VEEG).
5. Functional Magnetic Resonance Imaging (FMRI) can be used to identify each hemisphere of the brain functions.
6. A neurological assessment of the motor and cognitive abilities of the patient.
7. An imaging technique that tracks cerebral blood flow and metabolism is positron emission tomography (PET) or single-photon emission computed tomography (SPECT).

Estimated cost could consist of:

1. Approximately Rs. 50,000 is the average cost of a basic surgical checkup for epilepsy in India. An epilepsy diagnosis can be made in India for no more than Rs. 100,000 with a minimum surgical evaluation.
2. About Rs. 1,00,000 is usually required for an evaluation for sophisticated epilepsy surgery in India. The most one can pay in India for an advanced surgical assessment for epilepsy surgery is INR 2,00,000.
3. A consultation for more complex epilepsy surgery typically cost approximately Rs. 200,000 in India. It is possible to spend up to Rs. 4,00,000 in India for an extremely complex surgical assessment for epilepsy.

Success Rate of Epilepsy in Tuberous Sclerosis treatment in India?

The type of procedure and the specific conditions of the patient determine the success rate of epilepsy surgery. Research on epilepsy affecting the temporal lobes has shown that 59–72% of patients can successfully avoid seizures after surgery. According to studies, almost 64% of people do not experience seizures even after 20 years. After temporal lobe surgery, 75% of patients experienced no more seizures, and 59% of them remained seizure-free ten years later.

One minimally invasive method, laser ablation, has a “seizure freedom” rate of about 55%; in cases akin to those treated with resection, it can reach 699% or 75%. After hemisphere resection or hemispherectomy, between 45 and 80 percent of patients report significant improvements in seizure control, and occasionally seizure independence. Two elements determine whether epilepsy in Turberous Sclerosis treatment in India is effective: where the seizures occur in the brain and whether the technique is safe and doesn’t interfere with essential brain functions. With a high chance of seizure independence or a decrease in seizure frequency, epilepsy surgery can generally be a very successful therapeutic choice for those with uncontrollable seizures.