Hepatotoxicity: A hepatic injury or damage by drugs

Anju Bisht

, Health A2Z


This blog aims to explain hepatotoxicity by drugs and offer the best of our knowledge concerning the condition. The health condition, which is an adverse event, hard to diagnose, and if neglected, can lead to death. The hepatic injury or liver damage due to drug reaction is rare, but a serious condition. To get a better understanding of the condition, read ahead.


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Understand Hepatotoxicity


The condition is characterized as an injury or liver damage due to exposure to drugs or nonpharmacological agents. This allergic drug reaction may be unusual but is a very serious condition. Plus the condition can have a considerable impact on health.


The condition is of two type-


1. Intrinsic reaction: This drug reaction is dose-dependent, predictable, and less common.

2. Idiosyncratic reaction: Where this is not dose-dependent and vice versa to an intrinsic reaction.


Manifestation of Hepatotoxicity


The condition has several published research, but still not enough to be known around the world. Clinical and pathological manifestations incorporate:


  • Acute and chronic hepatitis: Acute is when it settles inside 6months and chronic last longer than 6 months.


  • Fulminant hepatitis: The condition in which the liver fails quickly.


  • Cholestasis: The condition where the flow of bile stops or becomes moderates from the liver.


  • Ductopenia: Ductopenia alludes to a lessening of intrahepatic bile ducts.


  • Granulomatous hepatitis: The condition is the localized collections of inflammatory cells, especially found in 2% to 10% of patients with liver biopsy.


  • Steatosis:  In this, there is an abnormal retention of fat in the cell or an organ.



For the most part, hepatotoxicity go along with nonspecific indications such as;


  • stomach pain




  • nervousness or anxiety


  • nausea


  • vomiting


  • diarrhea


  • itching and rash



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Risk factor Of Hepatotoxicity


The risk factors of the condition incorporate:


  • Age: Older adults are affected by the toxicity of drugs and the young population with valproic acid.


  • Gender: Females group is more prone to the condition. Certain factors may contribute to the same, such as menopause, pregnancy, and menstruation.



  • Associate administration of drugs or herbal remedies


  • History of underlying hepatic diseases


  • Genetic factors


  • Environmental factors



Hepatotoxicity: Prevention and Help



  • Prevention of the condition, this part depends upon the pharmacists; as they have to carry out the prevention activities. As in, giving legitimate guidance related to using medications and advancing the wellbeing of the patient.


  • Identification of the same can be troublesome since it has no particular and obvious symptoms. However, keep in mind the above nonspecific indications and the manifestation.


  • Next, go for some clinical scale developed such as the Roussel Uclaf Causality Assessment Method (CIOMS/RUCAM) and the Clinical Diagnostic Scale (M & V CDS).


  • Regardless of no particular treatment, there is a method based on suspending the suspected drug and treating symptoms.




Just as importantly- we have discussed all the important aspects of the Hepatotoxicity in the above blog. Do not overlook the symptoms of the condition and get immediate help, if any possibility, considering the risk factors. If you have any question then you can call us or connect us on WhatsApp on +91 9654030724.


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